Factor XIII Cross-Linked Adhesive Chitosan Hydrogels

Biomedical adhesives have been found to be an attractive alternative suturing in several circumstances. However, date most of the clinically approved formulations are based on synthetic and highly reactive toxic chemicals. In this work, we aimed combine for first time bioactive properties cationic polysaccharide chitosan its intrinsic electrostatic binding negatively charged tissues with biocompatible compliant enzymatic cross-linking scheme fibrin glue. This synergistic activity led generation a transglutaminase Factor XIII cross-linkable formulation fast gelation kinetics, tunable mechanical properties, antibacterial activity, strong adhesion cartilage.